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Bioscience

Glycomics

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Displaying 26 - 31 of 31

QUANTITY: An Isobaric Tag for Quantitative Glycomics

November 30, 2015

Author(s)

Shuang Yang, Meiyao Wang, Lijun Chen, Illarion Turko, Karen W. Phinney, Shuwei Li

We describe the design and synthesis of a novel set of iso-baric tags for quantitative glycan profiling, which will have broad applications in carbohydrate based biomarker dis-covery, therapeutic protein characterization, and vaccine development.

Glycan Analysis of NIST mAb Reference Material

October 15, 2015

Author(s)

John E. Schiel, Catherine A. Mouchahoir

N-linked glycosylation is a common post-translational modification that imparts structural heterogeneity to recombinant monoclonal antibody therapeutics. The various oligosaccharides attached to the CH2 domains of IgG can impact the efficacy, safety and

Universal Proteolysis and MSn for N- and O- Glycan Branching Analysis

April 20, 2013

Author(s)

John E. Schiel, Karen W. Phinney, Nicholas J. Smith

The continually growing list of critical glycosylation-related processes has made analytical methodology for detailed glycan characterization an area of increasing interest. Glycosylation is a post translational modification of unsurpassed complexity due