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Physics

Biological Physics

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Displaying 26 - 50 of 377

Micromechanical Compatibility Between Cells and Scaffolds Directs Phenotypic Transition of Stem Cells

January 28, 2022
Author(s)
Yang Song, Jiaoyue Long, Jeremiah Woodcock, Joy Dunkers, Hung Chun Lin, Douglas M. Fox, Xiaoling Liao, Yonggang Lv, Li Yang, Martin Chiang
This study experimentally substantiates the micromechanical compatibility between cell and substrate is essential for cells to achieve energetically favorable mechanotransduction that directs phenotypic transitions. The argument for this compatibility is

Quantification of urban biogenic carbon fluxes using bottom-up inventory and satellite-based model

January 5, 2022
Author(s)
Joy Winbourne, Hrstiana Stoynova, Ian Smith, Conor Gately, Barry Logan, Jaret Reblin, Andrew Reinmann, David W. Allen, Lucy Hutyra
Cities across the globe are taking the lead on climate mitigation action with ambitious goals to reduce carbon dioxide (CO2) emissions. The implementation of effective mitigation policies will require accurate measurements to guide policy decisions and

HDX-MS and MD simulations provide evidence for stabilization of the IgG1- FcgRIa (CD64a) immune complex through intermolecular glycoprotein bonds

December 8, 2021
Author(s)
Kyle Anderson, Kerry Scott, Christina Bergonzo, Ioannis Karageorgos, Elyssia Gallagher, Venkata Tayi, Michael Butler, Jeffrey W. Hudgens
Previous reports present different models for the stabilization of the Fc—FcγRI immune complex. Although accord exists on the importance of L235 in IgG1 and some hydrophobic contacts for complex stabilization, discord exists regarding the existence of

Blood vessel-on-a-chip examines biomechanics of microvasculature

November 15, 2021
Author(s)
Paul Salipante, Steven D. Hudson, Styliani Alimperti
We use a three-dimensional (3D) microvascular platform to measure the elasticity and membrane permeability of the endothelial cell layer. The microfluidic platform is connected with a pneumatic pressure controller to apply hydrostatic pressure. The

Nanopore sensing: a physical-chemical approach

September 1, 2021
Author(s)
Joseph W. Robertson, Madhav Ghimire, Joseph Reiner
Protein nanopores have emerged as an important class of sensor, for the understanding of biophysical processes, such as molecular transport across membranes, and detection and characterization of biopolymers. We trace the development of these sensors from

Origin and control of ionic hydration patterns in nanopores

June 18, 2021
Author(s)
Miraslau L. Barabash, William A. Gibby, Carlo Guardiani, Alexander Smolyanitsky, Dmitry G. Luchinsky, Peter V. McClintock
In order to permeate a nanopore, an ion must overcome a dehydration energy barrier caused by the redistribution of surrounding water molecules. The redistribution is inhomogeneous, anisotropic and strongly position-dependent, resulting in complex patterns