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Search Publications by: Michael J. Carrier (Fed)

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Displaying 26 - 32 of 32

The Metrology of Counting Protein Particles

March 18, 2013
Author(s)
Dean C. Ripple, Michael J. Carrier, Richard E. Cavicchi, Christopher B. Montgomery, Zhishang Hu
A common degradation pathway for protein-based drugs is the growth of protein aggregates or particles. Counting and characterization of these particles is needed to assure the quality, efficacy, and safety of this type of drug. The unusual physical

Standards for the Optical Detection of Protein Particulates

January 23, 2012
Author(s)
Dean C. Ripple, Michael J. Carrier, Joshua R. Wayment
Particulates in protein therapeutics, composed of agglomerated protein monomers, may cause an immunogenic response in patients. Consequently, industry and the FDA desire more accurate methods for counting and characterizing particulates. Unlike likely

Structure and Properties of Silica Nanoclusters at High Temperatures

June 1, 2002
Author(s)
I V. Schweigert, K E. Lehtinen, Michael J. Carrier, Michael R. Zachariah
The properties of silica clusters at temperatures from 1500 to 2800 K are investigated using classical molecular dynamics simulations for particles containing up to 1152 atoms. We found that atoms in the cluster were arranged in a shell-like structure at