Publications

Displaying 101 - 125 of 136

Effects of sample preparation on bacterial colonization of polymers

October 19, 2009

Author(s)

Diana N. Zeiger, Christopher Stafford, Yajun Cheng, Stefan D. Leigh, Sheng Lin-Gibson, Nancy Lin

Characterization of materials developed for medical usage frequently includes studies in which the materials are inoculated with bacteria in order to assess biofilm formation. Differences in the bacteria are considered to be due to the material alone; the

Microbial colonization on polymers: Effects of sample preparation and incorporation of quaternary ammonium salts

September 13, 2009

Author(s)

Nancy Lin, Diana N. Zeiger, Joseph M. Antonucci, Bruce O. Fowler, Christopher Stafford, Sheng Lin-Gibson

Controlling bacterial growth in the oral environment presents many challenges. To address these challenges, new materials and treatments are needed along with controlled, reproducible methods to evaluate their efficacy. In this study, a reproducible method

Effect of Nano-Silica Fillers on Surface Morphology and Mechanical Properties of Polymer-Silica Composites

August 20, 2009

Author(s)

Li Piin Sung, Dongmei Zhe, Aaron M. Forster, Peter Krommenhoek, Nancy J. Lin, Sheng Lin-Gibson

Investigation on the effect of nano-silica on the effect of nano-silica on the surface morphology and mechanical properties has been carried out on two-dimensional (2D) gradient polymer-silica composite samples varied in chemical composition (e.g., filler

Effects of Composite Filler Content and Surface Properties on Cellular Response

August 16, 2009

Author(s)

Nancy J. Lin, Sheng Lin-Gibson

Dimethacrylate-based composites have seen increased application in orthopedics, where materials are typically placed in direct contact with viable bone tissue. Since a number of material properties, including degree of conversion (DC), surface

Synthesis, characterization and evaluation of novel, anti-bacterial monomers for dental and biomedical applications

August 16, 2009

Author(s)

Joseph M. Antonucci, Bruce O. Fowler, Diana N. Zeiger, Nancy Lin, Sheng Lin-Gibson

Although progress has been made in reducing polymerization shrinkage through resin and filler phase modifications, and in designing improved dental adhesion systems, composite fillings still fail clinically because of bacterial infiltration and secondary

Quantification of cell response to polymeric composites using a two-dimensional gradient platform

August 6, 2009

Author(s)

Nancy Lin, Haiqing Hu, Li Piin Sung, Sheng Lin-Gibson

A simple and straightforward screening process to assess the toxicity and corresponding cell response of dental composites would be useful prior to extensive in vitro or in vivo characterization. To this end, gradient composite samples were prepared with

Nondestructive quantification of leakage and its correlation with material performance parameters

July 30, 2009

Author(s)

Jirun Sun, Rui Fang, Nancy Lin, Naomi Eidelman, Sheng Lin-Gibson

Current methods to determine debonding/leakage at the tooth-composite interphase are qualitative or semi-quantitative. Our previous work introduced a 3D imaging technique to determine and visualize leakage and its distribution at the interface of cavity

Osteoblast response to polymeric composites varying in composition, conversion and roughness using a combinatorial approach

June 10, 2009

Author(s)

Nancy J. Lin, Sheng Lin-Gibson

Dimethacrylates typically used in dental composites are seeing increased applications in orthopedics, applications where cell-material contact is highly likely and often encouraged. Some formulations of dimethacrylate polymers and composites have been

Combinatorial characterization of photopolymerizable composites: Effect of filler type and content on properties

March 22, 2009

Author(s)

Li Piin Sung, Aaron M. Forster, Haiqing Hu, Nancy Lin, Sheng Lin-Gibson

Multi-component formulations coupled with complex processing conditions govern the final properties of photopolymerizable dental composites. In this study, a single test substrate was fabricated to support multiple formulations with a gradient in degree of

Monitoring of elongation and orientation of osteoblast cells directed by anisotropic nanopatterns

March 22, 2009

Author(s)

Jirun Sun, Yifu Ding, Nancy Lin, Marcus T. Cicerone, Christopher Soles, Sheng Lin-Gibson

The time dependence of cell alignment and morphology (i.e., elongation) on anisotropic nanoscale gratings is characterized. The behavior of pre-osteoblasts cultured on nanoscale gradient patterns of transparent photopolymerized dimethacrylates was

Effects of filler type and content on mechanical properties of photopolymerizable composites determined using a two-dimensional gradient platform

February 5, 2009

Author(s)

Sheng Lin-Gibson, Li Piin Sung, Haiqing Hu, Aaron M. Forster, Nancy J. Lin

Photopolymerizable dental composites have complex processing conditions and multi-component formulations that affect the final properties. Combinatorial screening is a useful approach for evaluating multiple properties of the composites. A single test

Monitoring Alignment of Osteoblast Cells Directed by Gradient Nanopatterns

April 6, 2008

Author(s)

Jirun Sun, Yifu Ding, Nancy J. Lin, Hyun Wook Ro, Christopher L. Soles, Sheng Lin-Gibson

We investigated the behavior of pre-osteoblasts cultured on polystyrene and photopolymerized ethoxylated bisphenol-A dimethacrylate gradient patterns. Gradient patterns varying in height from several hundred to 0 nm were prepared using nanoimprinting

Mapping Cell Distribution in Amorphous Scaffolds using Confocal Microscopy

August 19, 2007

Author(s)

Jirun Sun, Nancy Lin, Marcus T. Cicerone, Sheng Lin-Gibson

One common method for probing cell-material interactions is direct visualization via confocal laser scanning microscopy, a technique widely used for studying biological systems. However, confocal microscopy has limited depth penetration for imaging cells

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