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Search Publications by: Andrew Slifka (Fed)

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Displaying 101 - 125 of 150

Stiffening of the Extrapulmonary Arteries in Chronic Hypoxic Pulmonary Hypertension

July 1, 2008
Author(s)
Elizabeth S. Drexler, J. E. Bischoff, Christopher N. McCowan, Andrew Slifka, Timothy P. Quinn, R Shandas, Dunbar Ivy, K. R. Stenmark
It is increasingly appreciated that changes in the compliance properties of large blood vessels are critical determinants of ventricular afterload and ultimately dysfunction. Little is known of the mechanical properties of large vessels in the setting of

A Uniaxial BioMEMS Device for Quantitative Force-Displacement Measurements

April 3, 2007
Author(s)
David Serrell, Tammy L. Oreskovic, Andrew Slifka, Roop L. Mahajan, Dudley Finch
There is a need for experimental techniques that allow the simultaneous imaging of cellular cystoskeletal components with quantitative force measurements on single cells. A bioMEMS device has been developed for the application of strain to a single cell

Strain-Induced Grain Growth during Rapid Thermal Cycling of Aluminum Interconnects

January 1, 2007
Author(s)
Robert Keller, Roy H. Geiss, Nicholas Barbosa, Andrew Slifka, David T. Read
We demonstrate by use of automated electron backscatter diffraction (EBSD) the rapid growth of grains in non-passivated, sputtered Al-1Si interconnects during 200 Hz thermal cycling induced by alternating electric current. Mean grain diameters were

Stress-strain behavior of rat pulmonary arteries

January 1, 2007
Author(s)
Elizabeth S. Drexler, J Wright, Andrew Slifka, Christopher N. McCowan, Dunbar Ivy, R Shandas
The stress-strain behavior of rat pulmonary arteries was studied using a bubble inflation technique. To obtain mechanical properties, an analytical method to evaluate the bubble test results was developed. A flat disk of rat pulmonary artery was

Electrical Methods for Mechanical Characterization of Interconnect Thin Films

September 1, 2005
Author(s)
Robert Keller, Cynthia A. Volkert, Roy H. Geiss, Andrew Slifka, David T. Read, Nicholas Barbosa, Reiner Monig
We describe the use of electrical methods for evaluating mechanical reliability and properties of patterned copper and aluminum interconnects on silicon substrates. The approach makes use of controlled Joule heating, which causes thermal strains in the

Implementation and Application of a Microstructurally Based Orthotropic Hyperelastic Model of Pulmonary Artery Mechanics under Normotensive and Hypertensive Conditions

August 1, 2005
Author(s)
Yang Zhang, Martin Dunn, Elizabeth S. Drexler, Christopher N. McCowan, Andrew Slifka, Dunbar Ivy, R Shandas
We implemented, validated, and applied a microstructurally based orthotropic hyperelastic constitutive model to simulate pulmonary artery mechanics under normotensive and hypoxic hypertensive conditions. The configuration of the model microstructure is a

Comparison of Strength Properties of Normotensive and Hypertensive Rat Pulmonary Arteries

October 1, 2004
Author(s)
Elizabeth S. Drexler, Christopher N. McCowan, J Wright, Andrew J. Slifka, Dunbar Ivy, Robin Shandas
A series of tests were conducted to quantify the difference in the mechanical properties of normo-and hypertensive pulmonary arteries. A bubble-test design was emplpoyed to measure the biaxial properties of a segment of artery. The test results compare the

Static and Quasi-static Calibration of Bio-MEMS Device

October 1, 2004
Author(s)
Andrew J. Slifka, Hrishikesh V. Panchawagh, Roop L. Mahajan, Dudley Finch, R. A. Rorrer
A bio-MEMS device which has been designed to stimulate cells by oscillatory actuation in the vertical direction has been calibrated. The displacement of this device was determined experimentally by a laser interferometer when actuated by a static voltage

An Experimental Method for Measuring Mechanical Properties of Rat Pulmonary Arteries Verified With Latex

June 1, 2003
Author(s)
Elizabeth S. Drexler, Andrew J. Slifka, J Wright, Christopher N. McCowan, Dudley Finch, Timothy P. Quinn, J D. McCloskey, Dunbar Ivy, Robin Shandas
A study of the biomechanics and hemodynamics of pulmonary hypertension is incomplete without including mechanical properties data comparing healthy and diseased arterial tissue. In the initial stabe of this study, Sprague-Dawley rats will be induced with