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Raymond Adkins, Joanna Robaszewski, Seungwoo Shin, Fridtjof Brauns, Leroy Jia, Ayantika Khanra, Prerna Sharma, Robert Pelcovits, Thomas Powers, Zvonimir Dogic
Liquid shells, such as lipid vesicles, emulsions, and soap bubbles, are ubiquitous throughout biology, engineered matter, and everyday life. Their creation or disintegration is defined by a singularity separating topologically distinct one-boundary
The editors introduce a Journal of Biomedical Optics (JBO) feature issue on "Hyperspectral imaging." The special issue features a number of important research and review papers on new hyperspectral imaging and detection devices and associated technologies
Xiaojun Wei, Dumei Ma, Junlin Ou, Ge Song, Jiawei Guo, Joseph Robertson, Yi Wang, Qian Wang, Chang Liu
Nanopores have demonstrated remarkable sensitivity as biosensors, enabling the sequencing of DNA and RNA at the single-molecule level. The rapid progress in this field has sparked interest in using nanopores for protein sequencing, although current
Xiaojun Wei, Tadas Penkauskas, Joseph Reiner, Mark Uline, Qian Wang, Sheng Li, Aleksei Aksimentiev, Joseph Robertson, Chang Liu
Biotechnological innovations have vastly improved the capacity to perform large-scale protein studies, while the methods we have of identifying and quantifying individual proteins are still inadequate to perform protein sequencing at the single-molecule
The use of microfluidics to make mechanical property measurements is increasingly common. Fabrication of microfluidic devices has enabled various types of flow control and sensor integration at micrometer length scales to interrogate biological materials
Rees Garmann, Aaron Goldfain, Cheylene Tanimoto, Christian Beren, Fernando Vasquez, Daniel Villarreal, Charles Knobler, William Gelbart, Vinothan Manoharan
Aaron Goldfain, Paul Lemaillet, David W. Allen, Kimberly Briggman, Jeeseong C. Hwang
We report on techniques to manufacture and characterize solid tissue-mimicking phantoms of polydimethylsiloxane (PDMS) polymers. Tunability of the absorption (a()) and reduced scattering spectra (s'()) in the wavelength range of 500 nm to 850 nm is
For hydrogen-deuterium exchange mass spectrometry (HDX-MS) to have an increased role in quality control of biopharmaceuticals, H for D back-exchange occurring during protein analyses should be minimized to promote greater reproducibility. Standard HDX-MS
Thomas C. Larason, Steven Grantham, Clarence Zarobila, Yuqin Zong, C Cameron Miller, Michael Schuit, Brian Holland, Stewart Wood, Melissa Krause
As COVID-19 was overtaking the world in the spring of 2020, the National Institute of Standards and Technology began collaborating with the National Biodefense Analysis and Countermeasures Center to study the inactivation of SARS-CoV-2 to different UV and
Daniel A. Fischer, Cherno Jaye, Katinka R. Holler, Mette H. Rasmussen, Joe E. Baio, Stanislav N. Gorb, Tobias Weidner
Geckos have the astonishing ability to climb on vertical surfaces due to the adhesive properties of fibrous setae at the tips of their toe pads. While the adhesion mechanism principle, based on van-der-Waals interactions of myriads of spatula located at
Ivan Burenkov, Sergey Polyakov, Juan J. Sabines Chesterking
Fluorescent biomarkers are used to detect target molecules within inhomogeneous populations of cells. When these biomarkers are found in trace amounts it becomes extremely challenging to detect their presence in a flow cytometer. Here, we present a