U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Search Publications by: Michael J. Tarlov (Fed)

Search Title, Abstract, Conference, Citation, Keyword or Author
Displaying 76 - 100 of 122

DNA-Based Sensors

January 1, 2003
Author(s)
Michael J. Tarlov, A B. Steel
The development of DNA-based sensors for genetic assay and sequencing applications has exploded over the last decade. Nearly all of these devices rely on the hybridization of a complementary oligonucleotide with surface-confined, single-stranded DNA or RNA

Immobilization of DNA Hydrogel Plugs in Microfluidic Channels

March 15, 2002
Author(s)
K G. Olsen, David J. Ross, Michael J. Tarlov
Acrylamide-modified DNA probes are immobilized in polycarbonate microfluidic channels via photopolymerization in a polyacrylamide matrix. The resulting polymeric, hydrogel plugs are porous under electrophoretic conditions and hybridize with fluorescently

DNA Hydrogel Plugs Immobilized in Microfluidic Channels with Improved Stability

February 28, 2002
Author(s)
Rebecca A. Zangmeister, K G. Olsen, David J. Ross, Michael J. Tarlov
It has been previously demonstrated that DNA, modified on the 5' end with an acrylic acid group, can be incorporated into a polyacrylamide hydrogel matrix. These types of DNA containing gels have recently been immobilized in plastic microfluidic channels

Surface Characterization of Laser- Ablated Polymers Used for Microfluidics

February 15, 2002
Author(s)
D L. Pugmire, E A. Waddell, R Haasch, Michael J. Tarlov, Laurie E. Locascio
Fabrication of microfluidic devices by excimer laser ablation under different atmospheres may provide variations in polymer microchannel surface characteristics. The surface chemistry and electroosmotic (EO) mobility of polymer microchannels laser ablated

Sol-Gel Materials for Gas Phase Sensing Using Microhotplate Arrays

February 1, 2002
Author(s)
N O. Savage, Richard E. Cavicchi, Michael J. Tarlov, Stephen Semancik, J Greg Gillen
Sol-gel chemistry is used to create suspensions (sols) of small particles of materials such as metal oxides. These suspensions can be dried to a gel or powder or used in the sol form for coatings and thin films. One promising application of sol-gel derived

Fabrication, Derivatization and Applications of Plastic Microfluidic Devices

February 1, 2001
Author(s)
S L. Barker, Michael J. Tarlov, David J. Ross, T J. Johnson, E A. Waddell, Laurie E. Locascio
Control of the polymer surface chemistry is a crucial aspect of development of plastic microfluidic devices. When commercially available plastic substrates are used to fabricate microchannels, differences in the electroosmotic flow mobility (EOF) from

A Surface Chemistry Study of Laser Ablated Plastics Used for Microfluidic Devices

January 1, 2001
Author(s)
D P. Pugmire, E A. Waddell, Michael J. Tarlov
Plastic substrates are being investigated for use in microfluidic devices because of their low cost, ease of fabrication, and wide range of materials properties. It is well established that the surface chemistry of a plastic substrate greatly influences

Control of Flow Direction in Microfluidic Devices with Polyelectrolyte Multilayers

December 1, 2000
Author(s)
S L. Barker, David J. Ross, Michael J. Tarlov, Michael Gaitan, Laurie E. Locascio
Electroosmotic flow (EOF) is commonly utilized in microfluidics. Because the direction of the EOF can be determined by the substrate surface charge, control of the surface chemical state offers the potential, in addition to voltage control, to direct the

Plastic Microfluidic Devices Modified With Polyelectrolyte Multilayers

October 15, 2000
Author(s)
S L. Barker, Michael J. Tarlov, H E. Canavan, J J. Hickman, Laurie E. Locascio
Control of the polymer surface chemistry is a crucial aspect of development of plastic microfluidic devices. When commercially available plastic substrates are used to fabricate microchannels, differences in the EOF mobility from plastic to plastic can be

Derivatization of Plastic Microfluidic Devices With Polyelectrolyte Multilayers

May 1, 2000
Author(s)
S L. Barker, Michael J. Tarlov, M L. Branham, J Xu, William A. MacCrehan, Michael Gaitan, Laurie E. Locascio
Microchannels fabricated in plastic materials by room temperature imprinting demonstrate large variability in surface charge as a result of the fabrication procedure. Surface charged groups are primarily localized on the channel walls and not on the